Term: Kidney Failure Risk Equation (KFRE)
Last Updated: 2015-12-03
Kidney Failure Risk Equation (KFRE) are a group of predictive models developed by
Tangri et al., 2011
that evaluate the short-term risk of progression to kidney failure among patients with moderate to severe chronic kidney disease (CKD).
The KFRE model used in Chartier et al. (2015) is based on laboratory data and demographic variables that predicts the risk of developing kidney (renal) failure. Variables include age, sex, protein levels in the urine and kidney function measured using estimated glomerular filtration rate (eGFR).
The formulas are:
p = Five-year risk of kidney failure
(t=1826) = Five-year survival rate for an individual with the average value of covariates in the risk equation and was 0.929 in the development dataset
Estimated Glomerular Filtration Rate (eGFR)
ln(ACR) = Natural logarithm of
Albumin-Creatinine Ratio (ACR)
male = Indicator for sex (male = 1, female = 0)
- age = Age (years) at test date
- Tangri N, Stevens LA, Griffith J, Tighiouart H, Djurdjey O, Naimark D, Levin A, Levey AS. A predictive model for progression of chronic kidney disease to kidney failure. JAMA 2011;305(15):1553-1559. [Abstract] (View)
- Chartier M, Dart A, Tangri N, Komenda P, Walld R, Bogdanovic B, Burchill C, Koseva I, McGowan K-L, Rajotte L. Care of Manitobans Living with Chronic Kidney Disease. Winnipeg, MB: Manitoba Centre for Health Policy, 2015. [Report] [Summary] [Updates and Errata] [Additional Materials] (View)
Manitoba Centre for Health Policy
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